What is the standard of review for a defendant who seeks to overturn his conviction at summation?

Vargas argues that the government engaged in prosecutorial misconduct during its rebuttal at summation such that his conviction must be reversed. "[A] defendant who seeks to overturn his conviction based on alleged prosecutorial misconduct in summation bears a heavy burden." United States v. Farhane, 634 F.3d 127, 167 (2d Cir. 2011). "He must show more than that a particular summation comment was improper. He must show that the comment, when viewed against the entire argument to the jury and in the context of the entire trial, was so severe and significant as to have substantially prejudiced him, depriving him of a fair trial." Id. The

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plain error standard of review applies where "the defendant did not object at trial to the statements forming the basis of his appeal." United States v. Williams, 690 F.3d 70, 75 (2d Cir. 2012).